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Genetics and Parkinson’s disease

Several gene mutations may possibly play a role in Parkinson’s disease, though this is rare.  Several families with gene mutations that cause Parkinson’s disease have been studied. One mutation is of the protein alpha-synuclein and is autosomal dominant. Other gene mutations are of the protein ubiquitin carboxy-terminal hydrolase and the gene LRKK2.  Genetic mutations which contribute to early onset Parkinsonn’s disease are having two extra copies of the gene alpha-synuclein, a mutation of a protein called parkin. Not everyone who has these gene mutations will develop Parkinson’s disease.

Additional resources that provide more information on genetics and Parkinson’s disease: