Several gene mutations may possibly play a role in Parkinson’s disease, though this is rare. Several families with gene mutations that cause Parkinson’s disease have been studied. One mutation is of the protein alpha-synuclein and is autosomal dominant. Other gene mutations are of the protein ubiquitin carboxy-terminal hydrolase and the gene LRKK2. Genetic mutations which contribute to early onset Parkinsonn’s disease are having two extra copies of the gene alpha-synuclein, a mutation of a protein called parkin. Not everyone who has these gene mutations will develop Parkinson’s disease.
Additional resources that provide more information on genetics and Parkinson’s disease:
- What Genes are Linked to Parkinson’s? (National Institutes of Health)
- Genetics and Parkinson’s Disease: What Have We Learned? (Parkinson’s Disease Foundation)
- What Genes are Linked to Parkinson’s Disease? (National Institute of Neurological Disorders and Stroke)